Suppression of erythropoiesis by actinomycin D. 3. The effect of actinomycin D on the hemoglobin level of bone marrow erythrocytes and erythroblasts.
نویسنده
چکیده
For the purpose of revealing whether or not hemoglobin synthesis is inhibited by the AMD, the author estimated the hemoglobin level of AMD treated anilmals by microspectrophotometer, and found that the hemoglobin levels of all the developmental stages of erythroid cells were not inhibited by the AMD. The data indicated that about one half of mRNA for hemoglobin is synthesized in the early stage of specialization with the supplementary synthesis at the later stages and all these mRNA is stable and insensitive to AMD. ∗PMID: 4244047 [PubMed indexed for MEDLINE] Copyright c ©OKAYAMA UNIVERSITY MEDICAL SCHOOL Acta Merl. Okayama 23, 387-392 (1969) SUPPRESSION OF ERYTHROPOIESIS BY ACTINOMYCIN D III. THE EEFECT OF ACTINOMYCIN D ON THE HEMO. GLOBIN LEVEL OF BONE MARROW ERYTHRO· CYTES AND ERYTHROBLASTS
منابع مشابه
Suppression of erythropoiesis by actinomycin D. I. Evolutional change of hemopoiesis by actinomycin D.
For the purpose of revealing whether the sensitivity of the erythropoiesis to actinomycin D (AMD) differs among different animal species, and to see the acting site of AMD on erythroid cell specialization stage, the author observed the hourly change of the blood cell counts and bone marrow cells after AMD administration to mice, rats and rabbits, and obtained the following results: 1. The data ...
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ورودعنوان ژورنال:
- Acta medicinae Okayama
دوره 23 6 شماره
صفحات -
تاریخ انتشار 1969